The Study and exploration of substances that enhance cognitive brain functions are called the study of Nootropics. History shows that the first ever kind of “smart” drugs is used to aid or cure people with motion sickness. Further studies revealed that it has potent memory enhancing properties and was also used in testing on Alzheimer’s disease patients with great results. Driven by the quest of how to increase brain power and memory, this branch of science continue with its research and development. These compounds can be “stacked” together, which means can be taken with other substances for a synergistic effect.
Racetam Class Nootropics
Piracetam is a nootropic of the racetam class – a kind of nootropic group known to improve memory, focus, mood, learning abilities, and improved energy levels. Most work with the neurotransmitter Acetylcholine, while others improve the reuptake of glutamate. For example, one can take a coluracetam stack and pair it with caffeine for a more active effect. Acetylcholine is crucial, as it aids in the signals sent across synapses. Racetams are also known to increase cell regrowth and decrease the rate of deterioration.
Studies and Research
As Piracetam is the oldest nootropic in the racetam group, Coluracetam is among the newest. It is very effective even in the lowest doses that’s why it is fast becoming a favorite, especially in the fight against depression. They are also known to have amazing benefits for MDD or major depressive disorder. This compound is unique among brain enhancers because it improves choline uptake in the nerve cells via the choline uptake system. This system increases the amount of acetylcholine in the brain and Coluracetam restore this choline uptake system even after nerve cell damage. Furthermore, it also protects the NMDA receptors from glutamate toxicity – which can come from strokes, traumatic brain injury, Alzheimer’s and other diseases that affect the brain. In a human control group study, the drug had a positive effect on depression score at very low doses. This is attributed to the compounds ability to decrease glutamate toxicity. The drug can also improve those with Anxiety disorders – and it is a marked improvement. Consider this, Coluracetam has a 20% improvement in anxiety levels versus Valiums 12%. It was also observed to promote nerve cell growth or neurogenesis. In laboratory testing, the compound increased and improved memory and learning in rats that were exposed to a nerve toxin. What is more intriguing is that the improvements lasted well beyond after the treatment. A more revealing result, however, is that the drug produced no effect in healthy brains.
With these positive effects listed but with very minimal human testing ever published, It is best to use this compound with the utmost of caution.